Cancer Dictionary (A)

A33

A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.

AAP

Alanine aminopeptidase. An enzyme that is used as a biomarker to detect damage to the kidneys, and that may be used to help diagnose certain kidney disorders. It is found at high levels in the urine when there are kidney problems. Also called alanine aminopeptidase.

abarelix (a-ba-REL-iks)

A drug used to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. It belongs to the family of drugs called gonadotropin-releasing hormone (GnRH) antagonists. Also called Plenaxis.

ABCD rating

A staging system for prostate cancer that uses ABCD. “A” and “B” refer to cancer that is confined to the prostate. “C” refers to cancer that has grown out of the prostate but has not spread to lymph nodes or other places in the body. “D” refers to cancer that has spread to lymph nodes or to other places in the body. Also called the Jewett staging system or the Whitmore-Jewett staging system.

abdomen (AB-doh-men)

The area of the body that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs.

abdominal

Having to do with the abdomen, which is the part of the body between the chest and the hips that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs.

abdominal x-ray (ab-DAH-mih-nul EX-ray)

An x-ray of the organs inside the abdomen. An x-ray is a type of radiation that can pass through the body and onto film, making pictures of areas inside the body. X-rays may be used to help diagnose disease.

abdominoperineal resection

Surgery to remove the anus, the rectum, and part of the sigmoid colon through an incision made in the abdomen. The end of the intestine is attached to an opening in the surface of the abdomen and body waste is collected in a disposable bag outside of the body. This opening is called a colostomy. Lymph nodes that contain cancer may also be removed during this operation.

aberrant crypt foci (uh-BAYR-unt KRIPT FOH-sy)

ACF. Clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci form before colorectal polyps and are one of the earliest changes that can be seen in the colon that may lead to cancer. Also called ACF.

ABI-007

A drug used to treat breast cancer that has spread or that has come back within 6 months after chemotherapy. It is also being studied in the treatment of newly diagnosed breast cancer and other types of cancer. ABI-007 is a type of mitotic inhibitor. Also called nanoparticle paclitaxel, protein-bound paclitaxel, paclitaxel albumin-stabilized nanoparticle formulation, and Abraxane.

ablation (a-BLAY-shun)

In medicine, the removal or destruction of a body part or tissue or its function. Ablation may be performed by surgery, hormones, drugs, radiofrequency, heat, or other methods.

abnormal

Not normal. An abnormal lesion or growth may be cancerous, premalignant (likely to become cancer), or benign.

Abraxane (uh-BRAX-ayn)

A drug used to treat breast cancer that has spread or that has come back within 6 months after chemotherapy. It is also being studied in the treatment of newly diagnosed breast cancer and other types of cancer. Abraxane is a type of mitotic inhibitor. Also called nanoparticle paclitaxel, protein-bound paclitaxel, paclitaxel albumin-stabilized nanoparticle formulation, and ABI-007.

abscess

An enclosed collection of pus in tissues, organs, or confined spaces in the body. An abscess is a sign of infection and is usually swollen and inflamed.

absorption (ub-SORP-shun)

The process of taking nutrients from the digestive system into the blood so they can be used in the body.

ABT-263

A substance being studied in the treatment of lymphomas and other types of cancer. It blocks some of the enzymes that keep cancer cells from dying. It is a type of Bcl-2 family inhibitor.

ABT-510

A substance being studied in the treatment of cancer. It is a type of angiogenesis inhibitor.

ABT-751

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called sulfonamides.

ABT-888

A substance being studied in the treatment of some types of cancer. It blocks enzymes that repair DNA damage caused by cancer treatments such as radiation and drugs. ABT-888 is a type of poly(ADP-ribose) polymerase inhibitor.

ABX-EGF

A human monoclonal antibody that is being used to treat colorectal cancer that has spread to other parts of the body. It is used in patients whose disease has not gotten better during or after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. ABX-EGF binds to the epidermal growth factor receptor (EGFR) and may block tumor cell growth. Also called panitumumab and Vectibix.

accelerated phase chronic myelogenous leukemia (ak-SEH-leh-ray-ted FAYZ KRAH-nik MY-eh-LAH-jeh-nus loo-KEE-mee-uh)

A phase of chronic myelogenous leukemia in which the disease is progressing. In this phase, 6% to 30% of the cells in the blood and bone marrow are blast cells (immature blood cells).

ACE inhibitor

Angiotensin-converting enzyme inhibitor. A drug that is used to lower blood pressure. An ACE inhibitor is a type of antihypertensive agent. Also called angiotensin-converting enzyme inhibitor.

acetaminophen

A drug that reduces pain and fever (but not inflammation). It belongs to the family of drugs called analgesics.

acetylcysteine

A drug usually used to reduce the thickness of mucus and ease its removal. It is also used to reverse the toxicity of high doses of acetaminophen. Also called N-acetylcysteine and N-acetyl-L-cysteine.

ACF

Aberrant crypt foci. Clusters of abnormal tube-like glands in the lining of the colon and rectum. ACF form before colorectal polyps and are one of the earliest changes that can be seen in the colon that may lead to cancer. Also called aberrant crypt foci.

achlorhydria (a-klor-HY-dree-a)

A lack of hydrochloric acid in the digestive juices in the stomach. Hydrochloric acid helps digest food.

acitretin

A substance that is used in the prevention of cancer and in the treatment of psoriasis. It belongs to the family of drugs called retinoids.

ACN53

A substance that has been studied in the treatment of some types of cancer. ACN53 is a weakened adenovirus that carries the p53 gene into tumor cells, causing them to die. It is a type of gene therapy. Also called recombinant adenovirus-p53, rAd/p53, and SCH-58500.

acne

A disorder of the skin in which oil glands and hair glands become inflamed.

acoustic (ah-KOOS-tik)

Having to do with sound or hearing.

acoustic neurofibromatosis (a-KOOS-tik NOOR-oh-fy-broh-muh-TOH-sis)

A genetic condition in which tumors form on the nerves of the inner ear and cause loss of hearing and balance. Tumors may also occur in the brain and on nerves in the skull and spinal cord, and may cause loss of speech, eye movement, and the ability to swallow. Also called neurofibromatosis type 2 and NF2.

acquired immunodeficiency syndrome (uh-KWY-erd IH-myoo-noh-dih-FIH-shun-see SIN-drome)

AIDS. A disease caused by human immunodeficiency virus (HIV). People with acquired immunodeficiency syndrome are at an increased risk for developing certain cancers and for infections that usually occur only in individuals with a weak immune system. Also called AIDS.

acridine carboxamide

DACA. A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor. Also called DACA.

acromegaly (A-kroh-MEH-guh-lee)

A condition in which the pituitary gland makes too much growth hormone after normal growth of the skeleton is finished. This causes the bones of the hands, feet, head, and face to grow larger than normal. Acromegaly can be caused by a pituitary gland tumor.

acrylonitrile (ak-ri-low-NYE-tril)

A substance used to make plastics, rubber, and textiles. Being exposed to acrylonitrile may increase the risk of developing certain cancers, such as lung, brain, or prostate cancer.

ACTH

A hormone made in the pituitary gland. ACTH acts on the outer part of the adrenal gland to control its release of corticosteroid hormones. More ACTH is made during times of stress. Also called adrenocorticotropic hormone and corticotropin.

Actinex

A drug put on the skin to treat growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer. Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth. Also called nordihydroguaiaretic acid, NDGA, and masoprocol.

actinic keratosis (ak-TIH-nik KAYR-uh-TOH-sis)

A precancerous condition of thick, scaly patches of skin. Also called solar keratosis and senile keratosis.

action study

In cancer prevention clinical trials, a study that focuses on finding out whether actions people take can prevent cancer.

Activase (AK-tih-VAYS)

A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent. Also called recombinant tissue plasminogen activator, r-tPA, and Alteplase.

activate

In biology, to stimulate a cell in a resting state to become active. This causes biochemical and functional changes in the activated cell.

activities of daily living

ADL. The tasks of everyday life. These activities include eating, dressing, getting into or out of a bed or chair, taking a bath or shower, and using the toilet. Instrumental activities of daily living are activities related to independent living and include preparing meals, managing money, shopping, doing housework, and using a telephone. Also called ADL.

Actos

A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a precancerous condition affecting the mouth) from developing into cancer. It belongs to the family of drugs called thiazolidinediones. Also called pioglitazone.

acupoint (AK-yoo-poynt)

A specific spot on the body where an acupuncture needle may be inserted to control pain and other symptoms. Also called an acupuncture point.

acupressure (AK-yoo-PREH-sher)

The application of pressure or localized massage to specific sites on the body to control symptoms such as pain or nausea. It is a type of complementary and alternative medicine.

acupuncture (AK-yoo-PUNK-cher)

The technique of inserting thin needles through the skin at specific points on the body to control pain and other symptoms. It is a type of complementary and alternative medicine.

acupuncture needle (AK-yoo-PUNK-cher NEE-dul)

A stainless steel needle that is slightly thicker than a human hair. Acupuncture needles are inserted through the skin at specific points on the body to control pain and other symptoms.

acupuncture point (AK-yoo-PUNK-cher poynt)

A specific spot on the body where an acupuncture needle may be inserted to control pain and other symptoms. Also called an acupoint.

acupuncture point injection (AK-yoo-PUNK-cher poynt in-JEK-shun)

A procedure in which drugs, vitamins, herbal extracts, or other fluids are injected into the body at an acupuncture point using a syringe and needle.

acustimulation

Mild electrical stimulation of acupuncture points to control symptoms such as nausea and vomiting.

acute (uh-KYOOT)

Symptoms or signs that begin and worsen quickly; not chronic.

acute leukemia (uh-KYOOT loo-KEE-mee-uh)

A rapidly progressing cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of white blood cells to be produced and enter the blood stream.

acute lymphoblastic leukemia (...LIM-foh-BLAS-tik loo-KEE-mee-uh)

ALL. A fast-growing type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called ALL and acute lymphocytic leukemia.

acute lymphocytic leukemia (...LIM-foh-SIH-tik loo-KEE-mee-uh)

ALL. A fast-growing type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called ALL and acute lymphoblastic leukemia.

acute myeloblastic leukemia (uh-KYOOT MY-eh-loh-BLAS-tik loo-KEE-mee-uh)

A quickly progressing disease in which too many immature white blood cells (not lymphocytes) are found in the blood and bone marrow. Also called AML, acute myeloid leukemia, acute myelogenous leukemia, acute nonlymphocytic leukemia, and ANLL.

acute myelogenous leukemia (uh-KYOOT MY-eh-LAH-jeh-nus loo-KEE-mee-uh)

A quickly progressing disease in which too many immature white blood cells (not lymphocytes) are found in the blood and bone marrow. Also called AML, acute myeloid leukemia, acute myeloblastic leukemia, acute nonlymphocytic leukemia, and ANLL.

acute myeloid leukemia (uh-KYOOT MY-eh-loyd loo-KEE-mee-uh)

A quickly progressing disease in which too many immature white blood cells (not lymphocytes) are found in the blood and bone marrow. Also called AML, acute myelogenous leukemia, acute myeloblastic leukemia, acute nonlymphocytic leukemia, and ANLL.

acute nonlymphocytic leukemia (uh-KYOOT non-lim-foh-SIH-tik loo-KEE-mee-uh)

A quickly progressing disease in which too many immature white blood cells (not lymphocytes) are found in the blood and bone marrow. Also called acute myelogenous leukemia, acute myeloid leukemia, acute myeloblastic leukemia, AML, and ANLL.

acute pain (uh-KYOOT payn)

Pain that comes on quickly, can be severe, but lasts a relatively short time.

acute promyelocytic leukemia (uh-KYOOT PRO-MY-eh-loh-SIH-tik loo-KEE-mee-uh)

APL. An aggressive (fast-growing) type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by an exchange of parts of chromosomes 15 and 17. Also called APL and promyelocytic leukemia.

acyclovir

A substance used to prevent or treat cytomegalovirus and herpes simplex infections that may occur when the body is immunosuppressed. It belongs to the family of drugs called antivirals.

AD 32

A drug used to treat bladder cancer that does not respond to BCG (Bacillus Calmette Guerin). It is an anthracycline and is a type of antitumor antibiotic. Also called valrubicin.

Adderall

A combination of drugs used as a treatment for attention deficit hyperactivity disorder (ADHD) and narcolepsy (a sleep disorder). It is a type of stimulant. Also called dextroamphetamine-amphetamine.

addiction

Uncontrollable craving, seeking, and use of a substance such as a drug or alcohol.

adenocarcinoma (A-den-oh-KAR-sih-NOH-muh)

Cancer that begins in cells that line certain internal organs and that have gland-like (secretory) properties.

adenoid cystic carcinoma (A-deh-noyd SIS-tik KAR-sih-NOH-muh)

A rare type of cancer that usually begins in the salivary glands.

adenoma (A-deh-NOH-muh)

A noncancerous tumor.

adenopathy (A-deh-NAH-puh-thee)

Large or swollen lymph glands.

adenosine triphosphate (uh-DEH-nuh-seen try-FOS-fayt)

ATP. A substance present in all living cells that provides energy for many metabolic processes and is involved in making RNA. Adenosine triphosphate made in the laboratory is being studied in patients with advanced solid tumors to see if it can decrease weight loss and improve muscle strength. Also called ATP.

adenosquamous carcinoma (A-den-oh-SKWAY-mus KAR-sih-NOH-muh)

A type of cancer that contains two types of cells: squamous cells (thin, flat cells that line certain organs) and gland-like cells.

adenovirus (A-den-oh-VY-rus)

A group of viruses that cause respiratory tract and eye infections. Adenoviruses used in gene therapy are altered to carry a specific tumor-fighting gene.

ADI-PEG 20

A substance being studied in the treatment of melanoma, liver cancer, and other types of cancer. It breaks down the amino acid arginine and may block the growth of cancer cells that need arginine to grow. It is a type of iminohydrolase. Also called pegylated arginine deiminase.

adjunct agent (A-junkt AY-jent)

In cancer therapy, a drug or substance used in addition to the primary therapy.

adjunct therapy (A-junkt THAYR-uh-pee)

Another treatment used together with the primary treatment. Its purpose is to assist the primary treatment. Also called adjunctive therapy.

adjunctive therapy (A-junk-tiv THAYR-uh-pee)

Another treatment used together with the primary treatment. Its purpose is to assist the primary treatment. Also called adjunct therapy.

adjustment disorder (uh-JUST-ment dis-OR-der)

A condition in which a person responds to a stressful event (such as an illness, job loss, or divorce) with extreme emotions and actions that cause problems at work and home.

adjuvant therapy (A-joo-vant THAYR-uh-pee)

Treatment given after the primary treatment to increase the chances of a cure. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, or biological therapy.

ADL

Activities of daily living. The tasks of everyday life. Basic ADLs include eating, dressing, getting into or out of a bed or chair, taking a bath or shower, and using the toilet. Instrumental activities of daily living (IADL) are activities related to independent living and include preparing meals, managing money, shopping, doing housework, and using a telephone. Also called activities of daily living.

administration (ad-MIH-nih-STRAY-shun)

In medicine, the act of giving a treatment, such as a drug, to a patient. It can also refer to the way it is given, the dose, or how often it is given.

adnexal mass (ad-NEK-sul…)

A lump in tissue near the uterus, usually in the ovary or fallopian tube. Adnexal masses include ovarian cysts, ectopic (tubal) pregnancies, and benign (noncancerous) or malignant (cancerous) tumors.

adrenal cancer (uh-DREE-nul KAN-ser)

Cancer that forms in the tissues of the adrenal glands (two glands located just above the kidneys). The adrenal glands make hormones that control heart rate, blood pressure, and other important body functions. Adrenal cancer that starts in the outside layer of the adrenal gland is called adrenocortical carcinoma. Adrenal cancer that starts in the center of the adrenal gland is called malignant pheochromocytoma.

adrenal cortex (uh-DREE-nul KOR-tex)

The outer part of the adrenal gland (a small organ on top of each kidney). The adrenal cortex makes androgen and corticosteroid hormones.

adrenal gland (uh-DREE-nul...)

A small gland that makes steroid hormones, adrenaline, and noradrenaline. These hormones help control heart rate, blood pressure, and other important body functions. There are two adrenal glands, one on top of each kidney. Also called suprarenal gland.

adrenal medulla (uh-DREE-nul meh-DOO-luh)

The inner part of the adrenal gland (a small organ on top of each kidney). The adrenal medulla makes chemicals such as epinephrine (adrenaline) and norepinephrine (noradrenaline) which are involved in sending nerve signals.

adrenalectomy (uh-DREE-nul-EK-toh-mee)

Surgery to remove one or both adrenal glands (a small organ on top of each kidney).

adrenaline

A hormone and neurotransmitter. Also called epinephrine.

adrenocortical (uh-DREE-noh-KOR-tih-kol)

Having to do with or made by the outer layer of the adrenal gland, which produces steroid hormones. There is an adrenal gland on top of each kidney.

adrenocortical cancer (uh-DREE-noh-KOR-tih-kol KAN-ser)

A rare cancer that forms in the outer layer of tissue of the adrenal gland (a small organ on top of each kidney that makes steroid hormones, adrenaline, and noradrenaline to control heart rate, blood pressure, and other body functions). Also called adrenocortical carcinoma and cancer of the adrenal cortex.

adrenocortical carcinoma (uh-DREE-noh-KOR-tih-kol KAR-sih-NOH-muh)

A rare cancer that forms in the outer layer of tissue of the adrenal gland (a small organ on top of each kidney that makes steroid hormones, adrenaline, and noradrenaline to control heart rate, blood pressure, and other body functions). Also called adrenocortical cancer and cancer of the adrenal cortex.

adrenocorticotropic hormone (uh-DREE-noh-KOR-tih-koh-TROH-pik HOR-mone)

ACTH. A hormone made in the pituitary gland. Adrenocorticotropic hormone acts on the outer part of the adrenal gland to control its release of corticosteroid hormones. More adrenocorticotropic hormone is made during times of stress. Also called corticotropin and ACTH.

Adriamycin PFS (AY-dree-uh-MY-sin …)

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium Streptomyces peucetius. It damages DNA (the molecules inside cells that carry genetic information) and stops cells from growing. Rapidly growing tumor cells that take up Adriamycin PFS may die. It is a type of anthracycline antitumor antibiotic. Also called doxorubicin hydrochloride, doxorubicin, Adriamycin RDF, and Rubex.

Adriamycin RDF (AY-dree-uh-MY-sin …)

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin RDF comes from the bacterium Streptomyces peucetius. It damages DNA (the molecules inside cells that carry genetic information) and stops cells from growing. Rapidly growing tumor cells that take up Adriamycin RDF may die. It is a type of anthracycline antitumor antibiotic. Also called doxorubicin hydrochloride, doxorubicin, Adriamycin PFS, and Rubex.

adult T-cell leukemia/lymphoma

ATLL. An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma caused by the human T-cell leukemia virus type 1 (HTLV-1). It is marked by bone and skin lesions, high calcium levels, and enlarged lymph nodes, spleen, and liver. Also called ATLL.

advance directive

A legal document that states the treatment or care a person wishes to receive or not receive if he or she becomes unable to make medical decisions (for example, due to being unconscious or in a coma). Some types of advance directives are living wills and do-not-resuscitate (DNR) orders.

advanced cancer (ad-VANST KAN-ser)

Cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment.

advanced malignant mesothelioma (...muh-LIG-nunt meh-zuh-thee-lee-OH-muh)

Malignant mesothelioma that is stage II, III, or IV.

adverse effect

An unwanted side effect of treatment.

adverse event (AD-vers eh-VENT)

An unexpected medical problem that happens during treatment with a drug or other therapy. Adverse events do not have to be caused by the drug or therapy, and they may be mild, moderate, or severe.

AE-941

A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels to solid tumors. It belongs to the family of drugs called angiogenesis inhibitors.

AEE788

A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase inhibitors and angiogenesis inhibitors.

AEG35156

A substance being studied in the treatment of some types of cancer. AEG35156 may block a protein called XIAP so that chemotherapy is able to kill more tumor cells. It is a type of antisense oligonucleotide. Also called GEM640.

aerobic

In biochemistry, reactions that need oxygen to happen or happen when oxygen is present.

aerobic metabolism

A chemical process in which oxygen is used to make energy from carbohydrates (sugars). Also called aerobic respiration, oxidative metabolism, and cell respiration.

aerobic respiration

A chemical process in which oxygen is used to make energy from carbohydrates (sugars). Also called oxidative metabolism, cell respiration, and aerobic metabolism.

aerodigestive tract

The combined organs and tissues of the respiratory tract and the upper part of the digestive tract (including the lips, mouth, tongue, nose, throat, vocal cords, and part of the esophagus and windpipe).

aerosolize

In medicine, to turn a liquid drug into a fine mist that can be inhaled.

aflatoxin (A-fluh-TOK-sin)

A harmful substance made by certain types of mold (Aspergillus flavus and Aspergillus parasiticus) that is often found on poorly stored grains and nuts. Consumption of foods contaminated with aflatoxin is a risk factor for primary liver cancer.

AFP

Alpha-fetoprotein. A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor. Also called alpha-fetoprotein.

AFP464

A substance being studied in the treatment of cancer. AFP464 kills cancer cells or stops them from dividing. It is a type of aminoflavone.

AG-013736

A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and protein tyrosine kinase inhibitors.

AG2037

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors.

AG3340

A substance that is being studied in the treatment of cancer. It is a matrix metalloproteinase inhibitor and belongs to the family of drugs called angiogenesis inhibitors. Also called prinomastat.

AG337

A substance that is being studied in the treatment of liver cancer. It belongs to the family of drugs called thymidylate synthase inhibitors. Also called Thymitaq and nolatrexed.

agent study

In cancer prevention, a clinical trial that studies whether taking certain medicines, vitamins, minerals, or food supplements can prevent cancer. Also called chemoprevention study.

agglutinin

A substance that makes particles (such as bacteria or cells) stick together to form a clump or a mass.

aggravating factor (A-gruh-VAY-ting FAK-ter)

Something that makes a condition worse. For example, tobacco smoke is an aggravating factor for asthma.

aggressive

A quickly growing cancer.

aggressive lymphoma

A type of lymphoma that grows and spreads quickly, and has severe symptoms. It is seen frequently in patients who are HIV-positive (AIDS-related lymphoma). Also called intermediate-grade lymphoma and high-grade lymphoma.

agitation (A-jih-TAY-shun)

A condition in which a person is unable to relax and be still. The person may be very tense and irritable, and become easily annoyed by small things. He or she may be eager to have an argument, and be unwilling to work with caregivers to make the situation better.

agnogenic myeloid metaplasia (ag-noh-JEN-ik MY-eh-loyd meh-tuh-PLAY-zhuh)

A progressive, chronic disease in which the bone marrow is replaced by fibrous tissue and blood is made in organs such as the liver and the spleen, instead of in the bone marrow. This disease is marked by an enlarged spleen and progressive anemia. Also called chronic idiopathic myelofibrosis, primary myelofibrosis, myelosclerosis with myeloid metaplasia, and idiopathic myelofibrosis.

agonist

A drug that triggers an action from a cell or another drug.

agranulocyte (ay-GRAN-yoo-loh-SITE)

A type of white blood cell. Monocytes and lymphocytes are agranulocytes.

AIDS

Acquired immunodeficiency syndrome. A disease caused by the human immunodeficiency virus (HIV). People with AIDS are at an increased risk for developing certain cancers and for infections that usually occur only in individuals with a weak immune system. Also called acquired immunodeficiency syndrome.

AIDS-related cancer (…reh-LAYT-id KAN-ser)

Certain cancer types that are more likely to occur in people who are infected with the human immunodeficiency virus (HIV). The most common types are Kaposi sarcoma and non-Hodgkin lymphoma. Other AIDS-related cancers include Hodgkin disease and cancers of the lung, mouth, cervix, and digestive system.

AJCC staging system (... STAY-jing SIS-tem)

A system developed by the American Joint Committee on Cancer for describing the extent of cancer in a patient’s body. The descriptions include TNM: T describes the size of the tumor and if it has invaded nearby tissue, N describes any lymph nodes that are involved, and M describes metastasis (spread of cancer from one body part to another).

alanine aminopeptidase

AAP. An enzyme that is used as a biomarker to detect damage to the kidneys, and that may be used to help diagnose certain kidney disorders. It is found at high levels in the urine when there are kidney problems. Also called AAP.

alanine transferase

An enzyme found in the liver and other tissues. A high level of alanine transferase released into the blood may be a sign of liver damage, cancer, or other diseases. Also called serum glutamate pyruvate transaminase or SGPT.

alanosine

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antimetabolites. Also called SDX-102.

albinism (AL-bye-niz-em)

A group of genetic conditions marked by little or none of the pigment melanin in the skin, hair, and/or eyes. People with albinism may have vision problems and white or yellow hair; reddish, violet, blue or brown eyes; and pale skin.

ALCL

An aggressive (fast-growing) type of non-Hodgkin lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver. Also called anaplastic large cell lymphoma.

alcohol (AL-kuh-hol)

A chemical substance found in beer, wine, and liquor. Alcohol is also found in some medicines, mouthwashes, essential oils (scented liquid taken from plants), and household products.

alcohol dependence

A disease in which a person craves alcohol, is unable to limit his or her drinking, needs to drink greater amounts to get the same effect, and has withdrawal symptoms after stopping alcohol use. Alcohol dependence affects physical and mental health, and causes problems with family, friends, and work. Also called alcoholism.

alcoholism (AL-kuh-HAW-LIH-zum)

A disease in which a person craves alcohol, is unable to limit his or her drinking, needs to drink greater amounts to get the same effect, and has withdrawal symptoms after stopping alcohol use. Alcoholism affects physical and mental health, and causes problems with family, friends, and work. Also called alcohol dependence.

Aldara (al-DAR-uh)

A drug used to treat early basal cell skin cancer and certain other skin conditions. It is being studied in the treatment of other types of cancer. Aldara is a type of biological response modifier. Also called imiquimod.

aldehyde (AL-deh-hide)

A type of chemical substance made from alcohol. Aldehydes are found in essential oils (scented liquid taken from plants).

aldesleukin (AL-des-LOO-kin)

A drug used to treat some types of cancer. It is an interleukin-2 (a cytokine normally made by immune cells in the body) that is made in the laboratory. Aldesleukin increases the activity and growth of white blood cells called T cells and B cells. It is a type of biological response modifier. Also called recombinant human interleukin-2 and Proleukin.

Aldrich syndrome (AL-drich SIN-drome)

An inherited immune disorder that occurs in young boys. It causes eczema (a type of skin inflammation), a decrease in the number of platelets (blood cells that help prevent bleeding), and frequent bacterial infections. People with Aldrich syndrome are at increased risk of developing leukemia and lymphoma. Also called Wiskott-Aldrich syndrome.

alefacept (uh-LEH-fuh-sept)

A drug that is used to treat certain skin conditions and is being studied in the treatment of cutaneous (skin-related) T-cell cancer and T-cell non-Hodgkin lymphoma. Alefacept is made by combining part of an antibody with a protein that blocks the growth some types of T cells. It is a type of fusion protein and immunosuppressant. Also called Amevive.

alemtuzumab

A type of monoclonal antibody used in the treatment of leukemia. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells. Also called Campath-1H.

alendronate sodium (uh-LEN-droh-nayt SOH-dee-um)

A drug used to treat certain bone conditions, such as osteoporosis and Paget disease of the bone. It is also being studied in the treatment of hypercalcemia (high levels of calcium in the blood) and bone pain caused by cancer. Alendronate sodium slows the breakdown of bone and prevents the loss of calcium. It is a type of bisphosphonate. Also called Fosamax.

Alimta (uh-LIM-tuh)

A drug that is used to treat malignant pleural mesothelioma and advanced non-small cell lung cancer and is being studied in the treatment of other types of cancer. It is a type of enzyme inhibitor. Also called pemetrexed disodium and LY231514.

alkalinization (AL-ka-LIN-ih-ZAY-shun)

The process by which a substance becomes an alkali. An alkali is the opposite of an acid.

alkaloid

A member of a large group of chemicals that are made by plants and have nitrogen in them. Some alkaloids have been shown to work against cancer.

Alkeran

A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents. Also called melphalan.

alkylating agent

A drug that is used in the treatment of cancer. It interferes with the cell's DNA and inhibits cancer cell growth.

ALL

Acute lymphoblastic leukemia. A fast-growing type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphoblastic leukemia and acute lymphocytic leukemia.

all-trans retinoic acid (all-tranz REH-tih-NOH-ik A-sid)

ATRA. A form of vitamin A that is made by the body and can also be made in the laboratory. It is used to treat acute promyelocytic leukemia, usually together with other drugs, and to treat acne. It is being studied in the treatment and prevention of other types of cancer. Also called ATRA, tretinoin, retinoic acid, and vitamin A acid.

allergen (AL-er-jen)

A substance that causes an allergic response. Examples include pollen, molds, and certain foods.

allergic response (uh-LER-jik reh-SPONTS)

A hypersensitive immune reaction to a substance that normally is harmless or would not cause an immune response in most people. An allergic response may cause harmful symptoms such as itching or inflammation or tissue injury.

allogeneic (A-loh-jeh-NAY-ik)

Taken from different individuals of the same species. Also called allogenic.

allogeneic bone marrow transplantation (A-loh-jeh-NAY-ik bone MAYR-oh tranz-plan-TAY-shun)

A procedure in which a person receives stem cells (cells from which all blood cells develop) from a genetically similar, but not identical, donor.

allogeneic stem cell transplantation (A-loh-jeh-NAY-ik stem sel tranz-plan-TAY-shun)

A procedure in which a person receives blood-forming stem cells (cells from which all blood cells develop) from a genetically similar, but not identical, donor. This is often a sister or brother, but could be an unrelated donor.

allogenic

Taken from different individuals of the same species. Also called allogeneic.

allopathic medicine (A-loh-PA-thik MEH-dih-sin)

A system in which medical doctors and other healthcare professionals (such as nurses, pharmacists, and therapists) treat symptoms and diseases using drugs, radiation, or surgery. Also called conventional medicine, Western medicine, mainstream medicine, orthodox medicine, and biomedicine.

allopurinol

A drug that lowers high levels of uric acid (a byproduct of metabolism) in the blood caused by some cancer treatments.

Allovectin-7

A substance that is being studied as a gene therapy agent in the treatment of cancer. It increases the ability of the immune system to recognize cancer cells and kill them.

aloe-emodin

A substance found in certain plants, including aloe vera. It belongs to a family of compounds called anthraquinones, which have shown anti-inflammatory and anticancer effects.

alopecia (al-oh-PEE-shuh)

The lack or loss of hair from areas of the body where hair is usually found. Alopecia can be a side effect of some cancer treatments.

Aloxi (uh-LOK-see)

A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic. Also called palonosetron hydrochloride.

alpha-fetoprotein (AL-fuh-FEE-toh-PROH-teen)

AFP. A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor. Also called AFP.

alpha-lipoic acid (AL-fuh-lih-POH-ik A-sid)

A substance that is being studied for its ability to protect normal cells from the side effects of chemotherapy and prevent peripheral neuropathy (numbness, tingling, burning, and weakness in the hands or feet). Alpha-lipoic acid is made by the body and can be found in foods such as organ meats, spinach, broccoli, peas, brussel sprouts, and rice bran. It can also be made in the laboratory. Alpha-lipoic acid is a type of antioxidant and chemoprotective agent.

alprazolam (al-PRAY-zoh-lam)

A drug used to treat anxiety disorders and panic attacks. It is being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine. Also called Xanax.

Alteplase (AL-teh-PLAYS)

A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent. Also called recombinant tissue plasminogen activator, r-tPA, and Activase.

alteration

A change resulting in something that is different from the original.

alternative medicine (all-TER-nuh-tiv MEH-dih-sin)

Practices used instead of standard treatments. They generally are not recognized by the medical community as standard or conventional medical approaches. Examples of alternative medicine include dietary supplements, megadose vitamins, herbal preparations, special teas, acupuncture, massage therapy, magnet therapy, spiritual healing, and meditation.

altretamine

An anticancer drug that belongs to the family of drugs called alkylating agents.

alum

A type of immune adjuvant (a substance used to help boost the immune response to a vaccine). Also called aluminum sulfate.

aluminum sulfate

A type of immune adjuvant (a substance used to help boost the immune response to a vaccine). Also called alum.

ALVAC-CEA vaccine

A cancer vaccine containing a canary pox virus (ALVAC) combined with the human carcinoembryonic antigen (CEA) gene.

alveoli (al-VEE-oh-ly)

Tiny air sacs at the end of the bronchioles in the lungs.

Alzheimer dementia (ALTS-hy-mer dih-MEN-shuh)

A brain disorder that usually starts in late middle age or old age and gets worse over time. Symptoms include loss of memory, confusion, difficulty thinking, and changes in language, behavior, and personality. Also called Alzheimer disease.

Alzheimer disease (ALTS-hy-mer dih-ZEEZ)

A brain disorder that usually starts in late middle age or old age and gets worse over time. Symptoms include loss of memory, confusion, difficulty thinking, and changes in language, behavior, and personality. Also called Alzheimer dementia.

Amanita phalloides

A type of poisonous mushroom that has harmful effects on the kidneys and liver. It is responsible for most fatal cases of mushroom poisoning. Also called death cap.

Ambien

A drug used to treat insomnia (inability to sleep), and anxiety. It is a type of imidazopyridine (sedative hypnotic). Also called zolpidem.

AMD3100

A substance that is being studied for its ability to move stem cells out of the bone marrow and into circulating blood where they can be collected for use in stem cell transplantation. Stem cell transplantation is a method of replacing blood-forming stem cells that were destroyed by cancer treatment. AMD3100 belongs to the families of drugs called stem cell mobilizers and CXCR4 inhibitors.

amelanotic melanoma (AY-meh-luh-NAH-tik MEH-luh-NOH-muh)

A type of skin cancer in which the cells do not make the pigment melanin. Skin lesions are often irregular and may be pink, red, or have light brown, tan, or gray at the edges.

amethopterin (uh-meth-OPE-TAYR-in)

A drug used to treat some types of cancer, severe skin conditions such as psoriasis, and rheumatoid arthritis. Amethopterin stops cells from making DNA. It is a type of antimetabolite. Also called methotrexate and Rheumatrex.

Amevive (AM-eh-veev)

A drug that is used to treat certain skin conditions and is being studied in the treatment of cutaneous (skin-related) T-cell cancer and T-cell non-Hodgkin lymphoma. Amevive is made by combining part of an antibody with a protein that blocks the growth some types of T cells. It is a type of fusion protein and immunosuppressant. Also called alefacept.

AMG 162

A type of monoclonal antibody being studied in the treatment of multiple myeloma (a cancer that forms in bones) and in the prevention and treatment of bone metastases (cancer that has spread to bone from another organ). Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. AMG 162 binds to the protein RANKL and helps keep bone from breaking down. Also called denosumab.

AMG 706

A substance that is being studied in the treatment of some types of cancer. It belongs to the families of drugs called angiogenesis inhibitors and protein kinase inhibitors.

amifostine

A drug used as a chemoprotective drug to control some of the side effects of chemotherapy and radiation therapy.

amikacin

An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics.

amino acid (uh-MEE-noh A-sid)

One of several molecules that join together to form proteins. There are 20 common amino acids found in proteins.

amino acid sequence (uh-MEE-noh A-sid SEE-kwents)

The arrangement of amino acids in a protein. Proteins can be made from 20 different kinds of amino acids, and the structure and function of each protein are determined by the kinds of amino acids used to make it and how they are arranged.

aminocamptothecin

An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.

aminoglutethimide (a-MEE-no-gloo-TETH-ih-mide)

An anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Aminoglutethimide is used to decrease the production of sex hormones (estrogen in women or testosterone in men) and suppress the growth of tumors that need sex hormones to grow.

aminoglycoside antibiotic

A type of antibiotic that works against many types of bacteria and includes streptomycin, gentamicin, and neomycin. Aminoglycosides are used to treat bacterial infections.

aminolevulinic acid (uh-MEE-noh-lev-yoo-LIN-ik A-sid)

The active ingredient in a drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent.

aminolevulinic acid hydrochloride (uh-MEE-noh-lev-yoo-LIN-ik A-sid HY-droh-KLOR-ide)

A drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid hydrochloride is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent. Also called Levulan and Levulan Kerastick.

aminopterin

An anticancer drug that belongs to the family of drugs called antimetabolites.

AML

A quickly progressing disease in which too many immature white blood cells (not lymphocytes) are found in the blood and bone marrow. Also called acute myelogenous leukemia, acute myeloid leukemia, acute myeloblastic leukemia, acute nonlymphocytic leukemia, and ANLL.

amonafide

A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.

amoxicillin (uh-mok-see-SIH-lun)

A drug used to treat some bacterial infections. Amoxicillin is a form of penicillin that is made in the laboratory. It weakens the bacterial cell wall and causes the bacteria to break apart. It is a type of antibiotic.

amoxicillin-clavulanate potassium (uh-mok-sih-SIH-lin kla-vyoo-LAN-ayt puh-TA-see-um)

A drug used to treat bacterial infections. Adding the chemical clavulanate potassium to the antibiotic amoxicillin increases the amount of time the antibiotic stays active in the body. Amoxicillin-clavulanate potassium is a type of combination antibiotic. Also called Augmentin.

amphotericin B (AM-fuh-TAYR-ih-sin ...)

A drug used in the treatment of infections caused by fungi. It is a type of antifungal.

Amplimexon (AM-plih-MEK-son)

A substance that is being studied in the treatment of some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma. It belongs to the family of drugs called cyanoaziridine derivatives. Also called imexon.

ampulla

A sac-like enlargement of a canal or duct.

ampulla of Vater

An enlargement of the ducts from the liver and pancreas at the point where they enter the small intestine.

ampulla of Vater cancer (am-PUH-luh ... VAH-ter KAN-ser).

Cancer that forms in the ampulla of Vater (an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine). Symptoms include jaundice, abdominal pain, nausea, vomiting, and weight loss. Also called ampullary cancer.

ampullary cancer (am-PUH-layr-ee KAN-ser)

Cancer that forms in the ampulla of Vater (an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine). Symptoms include jaundice, abdominal pain, nausea, vomiting, and weight loss. Also called ampulla of Vater cancer.

amputation (am-pyoo-TAY-shun)

Surgery to remove part or all of a limb or appendage.

amrubicin (am-ROO-bih-sin)

A substance being studied in the treatment of lung cancer. It is a type of anthracycline analog.

amsacrine

An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.

amygdalin (uh-MIG-duh-lin)

A substance found in the pits of many fruits such as apricots and papayas, and in other foods. It has been tried in some countries as a treatment for cancer, but it has not been shown to work in clinical studies. Amygdalin is not approved for use in the United States. Also called laetrile.

amylase (AM-il-aze)

An enzyme that helps the body digest starches.

amyloidosis (am-a-loy-DOE-sis)

A group of diseases in which protein is deposited in specific organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause) or secondary (caused by another disease, including some types of cancer). Generally, primary amyloidosis affects the nerves, skin, tongue, joints, heart, and liver; secondary amyloidosis often affects the spleen, kidneys, liver, and adrenal glands.

anagrelide (an-AG-re-lide)

A drug that is used to decrease the number of platelets in the blood in order to prevent blood clotting.

anakinra (an-a-KIN-ra)

A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist. Also called Kinaret.

anal (AY-nul)

Having to do with the anus. The anus is the opening of the rectum (last part of the large intestine) to the outside of the body.

anal cancer (AY-nul KAN-ser)

Cancer that forms in tissues of the anus. The anus is the opening of the rectum (last part of the large intestine) to the outside of the body.

analgesia (AN-ul-JEE-zee-uh)

Pain relief.

analgesic

A drug that reduces pain. Analgesics include aspirin, acetaminophen, and ibuprofen.

analog

In chemistry, a substance that is similar, but not identical, to another.

analysis

A process in which anything complex is separated into simple or less complex parts.

anaphylactic shock (A-nuh-fih-LAK-tik shok)

A severe and sometimes life-threatening immune system reaction to an antigen that a person has been previously exposed to. The reaction may include itchy skin, edema, collapsed blood vessels, fainting, difficulty in breathing, and death.

anaplastic (an-ah-PLAS-tik)

A term used to describe cancer cells that divide rapidly and have little or no resemblance to normal cells.

anaplastic large cell lymphoma (A-nuh-PLAS-tik ... lim-FOH-muh)

An aggressive (fast-growing) type of non-Hodgkin lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver. Also called ALCL.

anaplastic thyroid cancer (A-nuh-PLAS-tik THY-royd KAN-ser)

A rare, aggressive type of thyroid cancer in which the malignant (cancer) cells look very different from normal thyroid cells.

anastomosis (an-AS-ta-MO-sis)

A procedure to connect healthy sections of tubular structures in the body after the diseased portion has been surgically removed.

anastrozole

An anticancer drug that is used to decrease estrogen production and suppress the growth of tumors that need estrogen to grow. It belongs to the family of drugs called nonsteroidal aromatase inhibitors.

anatomic (A-nuh-TAH-mik)

Having to do with anatomy (the study of the structure of a plant or animal).

anatomy (uh-NA-toh-mee)

The study of the structure of a plant or animal.

ancestim (an-SESS-tim)

A drug that is being studied for its ability to increase the number of stem cells in the blood. It belongs to the family of drugs called hematopoietic cell growth factors. Also called stem cell factor, SCF, and Stemgen.

androblastoma (AN-droh-blas-TOH-muh)

A rare type of ovarian tumor in which the tumor cells secrete a male sex hormone. This may cause virilization (the appearance of male physical characteristics in females). Also called arrhenoblastoma and Sertoli-Leydig cell tumor of the ovary.

androgen (AN-droh-jen)

A type of hormone that promotes the development and maintenance of male sex characteristics.

androgen ablation (AN-droh-jen a-BLAY-shun)

Treatment to suppress or block the production or action of male hormones. This is done by having the testicles removed, by taking female sex hormones, or by taking drugs called antiandrogens. Also called androgen suppression and androgen deprivation.

androgen deprivation (AN-droh-jen DEH-prih-VAY-shun)

Treatment to suppress or block the production or action of male hormones. This is done by having the testicles removed, by taking female sex hormones, or by taking drugs called antiandrogens. Also called androgen suppression and androgen ablation.

androgen suppression (AN-droh-jen suh-PREH-shun)

Treatment to suppress or block the production or action of male hormones. This is done by having the testicles removed, by taking female sex hormones, or by taking drugs called antiandrogens. Also called androgen ablation and androgen deprivation.

androgen-independent (AN-droh-jen...)

Describes the ability of tumor cells to grow in the absence of androgens (hormones that promote the development and maintenance of male sex characteristics). Many early prostate cancers require androgens for growth, but advanced prostate cancers are often androgen-independent.

anecdotal report

An incomplete description of the medical and treatment history of one or more patients. Anecdotal reports may be published in places other than peer-reviewed, scientific journals.

anemia (a-NEE-mee-a)

A condition in which the number of red blood cells is below normal.

anesthesia (A-nes-THEE-zhuh)

Drugs or substances that cause loss of feeling or awareness. Local anesthetics cause loss of feeling in a part of the body. General anesthetics put the person to sleep.

anesthesiologist (a-nes-THEE-zee-AH-loh-jist)

A doctor who specializes in giving drugs or other agents to prevent or relieve pain during surgery or other procedures being done in the hospital.

anesthetic (a-nes-THEH-tik)

A substance that causes loss of feeling or awareness. Local anesthetics cause loss of feeling in a part of the body. General anesthetics put the person to sleep.

anetholtrithione

A substance that is being studied in the treatment of cancer.

angelica root (an-JEH-lih-kuh root)

The root of any of a group of herbs called Angelica. It has been used in some cultures to treat certain medical problems, including gastrointestinal problems such as loss of appetite, feelings of fullness, and gas.

angiogenesis (AN-jee-oh-JEN-eh-sis)

Blood vessel formation. Tumor angiogenesis is the growth of new blood vessels needed for tumors to grow. This is caused by the release of chemicals by the tumor.

angiogenesis inhibitor (AN-jee-oh-JEN-eh-sis in-HIH-bih-ter)

A substance that may prevent the formation of blood vessels. In anticancer therapy, an angiogenesis inhibitor prevents the growth of new blood vessels needed for tumors to grow.

angiogram (AN-jee-oh-gram)

An x-ray of blood vessels. The person receives an injection of dye to outline the vessels on the x-ray.

angiography (an-jee-AH-gruh-fee)

A procedure to x-ray blood vessels. The blood vessels can be seen because of an injection of a dye that shows up in the x-ray.

angioimmunoblastic T-cell lymphoma

An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma marked by enlarged lymph nodes and hypergammaglobulinemia (increased antibodies in the blood). Other symptoms may include a skin rash, fever, weight loss, or night sweats.

angiomyolipoma (AN-jee-oh-MY-oh-lih-POH-muh)

A benign (noncancer) tumor of fat and muscle tissue that usually is found in the kidney. Angiomyolipomas rarely cause symptoms, but may bleed or grow large enough to be painful or cause kidney failure. They are common in patients with tuberous sclerosis (a genetic disorder in which benign tumors grow in the kidneys, brain, eyes, heart, lungs, and skin, causing seizures, mental problems, and skin lesions).

angiosarcoma (AN-jee-o-sar-KO-ma)

A type of cancer that begins in the cells that line blood vessels or lymph vessels. Cancer that begins in blood vessels is called hemangiosarcoma. Cancer that begins in lymph vessels is called lymphangiosarcoma.

angiostatin (AN-jee-oh-STA-tin)

A protein normally made by the body. It can also be made in the laboratory, and is being studied in the treatment of cancer. Angiostatin may prevent the growth of new blood vessels needed for tumors to grow. It is a type of angiogenesis inhibitor.

angiotensin-converting enzyme inhibitor

ACE inhibitor. A drug that is used to lower blood pressure. An angiotensin-converting enzyme inhibitor is a type of antihypertensive agent. Also called ACE inhibitor.

Angiozyme

A substance that is being studied in the treatment of kidney cancer. It may prevent the growth of blood vessels from surrounding tissue to the tumor. It belongs to the families of drugs called VEGF receptor and angiogenesis inhibitors. Also called RPI.4610.

anhydrovinblastine

An anticancer drug that belongs to the family of drugs called mitotic inhibitors.

anidulafungin

A drug that is used to treat infections caused by fungi. It belongs to the family of drugs called antifungals.

animal model

An animal with a disease either the same as or like a disease in humans. Animal models are used to study the development and progression of diseases and to test new treatments before they are given to humans. Animals with transplanted human cancers or other tissues are called xenograft models.

animal study (AN-ih-mul STUH-dee)

A laboratory experiment using animals to study the development and progression of diseases. Animal studies also test how safe and effective new treatments are before they are tested in people.

animal-assisted therapy (A-nih-mul-uh-SIS-ted THAYR-uh-pee)

A type of therapy that uses dogs or other pets to improve the physical and mental health of patients with certain acute or chronic diseases. It is being studied as a way to relieve distress in cancer patients undergoing treatment for pain. Also called pet-facilitated therapy.

ANLL

A quickly progressing disease in which too many immature white blood cells (not lymphocytes) are found in the blood and bone marrow. Also called acute nonlymphocytic leukemia, acute myelogenous leukemia, acute myeloblastic leukemia, acute myeloid leukemia, and AML.

annamycin

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anthracycline antibiotics.

anorexia

An abnormal loss of the appetite for food. Anorexia can be caused by cancer, AIDS, a mental disorder (i.e., anorexia nervosa), or other diseases.

anorexia nervosa

An eating disorder marked by an intense fear of gaining weight, a refusal to maintain a healthy weight, and a distorted body image. People with anorexia nervosa have an abnormal loss of appetite for food, try to avoid eating, and eat as little as possible.

ANS

Autonomic nervous system. The part of the nervous system that controls muscles of internal organs (such as the heart, blood vessels, lungs, stomach, and intestines) and glands (such as salivary glands and sweat glands). One part of the ANS helps the body rest, relax, and digest food and another part helps a person fight or take flight in an emergency. Also called autonomic nervous system and involuntary nervous system.

ansamycin

An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics.

antagonist

In medicine, a substance that stops the action or effect of another substance. For example, a drug that blocks the stimulating effect of estrogen on a tumor cell is called an estrogen receptor antagonist.

anterior (an-TEER-ee-er)

In human anatomy, has to do with the front of a structure, or a structure found toward the front of the body.

anterior mediastinotomy (an-TEER-ee-er MEE-dee-A-stih-NAH-toh-mee)

A procedure in which a tube is inserted into the chest to view the tissues and organs in the area between the lungs and between the breastbone and heart. The tube is inserted through an incision next to the breastbone. This procedure is usually used to get a tissue sample from the lymph nodes on the left side of the chest. Also called Chamberlain procedure.

anterior mediastinum

The area in the front part of the chest between the lungs. Also called prevascular space.

anterior pelvic exenteration (an-TEER-ee-er PEL-vik ek-ZEN-ter-AY-shun)

Surgery to remove the urethra, lower part of the ureters, uterus, cervix, vagina, and bladder.

anterior urethral cancer (an-TEER-ee-er yoo-REE-thrul KAN-ser)

A disease in which malignant (cancer) cells are found in the part of the urethra (the tube through which urine leaves the body) that is closest to the outside of the body.

anthracenedione

An anticancer drug that belongs to the family of drugs called anticancer antibiotics.

anthracycline

A type of antibiotic that comes from the fungus Streptococcus peucetius. Anthracyclines are used as treatments for cancer. Daunorubicin, doxorubicin, and epirubicin are anthracyclines.

anthraquinone

A type of anticancer drug.

anti-CD19 immunotoxin (… IH-myoo-noh-TOK-sin)

A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B-cell cancer. Anti-CD19 immunotoxin is made in the laboratory. It binds to CD19, a protein on the surface of normal B cells and B-cell tumors, and kills the cells.

anti-CD22 immunotoxin (… IH-myoo-noh-TOK-sin)

A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B-cell cancer. Anti-CD22 immunotoxin is made in the laboratory. It binds to CD22, a protein on the surface of normal B cells and B-cell tumors, and kills the cells.

anti-CD22 immunotoxin CAT-8015 (… IH-myoo-noh-TOK-sin …)

A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B-cell cancer. Anti-CD22 immunotoxin CAT-8015 is made in the laboratory. It binds to CD22, a protein on the surface of normal B cells and B-cell tumors, and kills the cells. Also called CAT-8015.

anti-CEA antibody

An antibody against carcinoembryonic antigen (CEA), a protein present on certain types of cancer cells.

anti-EpCAM-Pseudomonas-exotoxin fusion protein (...SOO-doh-MOH-nus-EK-soh-TOK-sin FYOO-zhun PROH-teen)

A substance being studied in the treatment of certain types of head and neck cancer. Anti-EpCAM-Pseudomonas-exotoxin fusion protein is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. It binds to EpCAM (a protein on the surface of epithelial cells and some types of cancer cells). Also called VB4-845 and Proxinium.

anti-idiotype vaccine

A vaccine made of antibodies that see other antibodies as the antigen and bind to it. Anti-idiotype vaccines can stimulate the body to produce antibodies against tumor cells.

anti-IL-6 chimeric monoclonal antibody (...ky-MEER-ik MAH-noh-KLOH-nul AN-tih-BAH-dee)

A chimeric (made from human and mouse proteins) monoclonal antibody being studied in the treatment of advanced kidney cancer and other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-IL-6 chimeric monoclonal antibody works by blocking inflammation and tumor growth. Also called CNTO 328 and cCLB8.

anti-inflammatory

Having to do with reducing inflammation.

anti-mesothelin monoclonal antibody MORAb-009 (AN-tee-mez-oh-THEE-lin MAH-noh-KLOH-nul AN-tee-BAH-dee…)

A monoclonal antibody being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-mesothelin monoclonal antibody MORAb-009 binds to mesothelin (a protein that is made by some cancer cells) and stops the cells from dividing. Also called MORAb-009.

anti-TGF-beta monoclonal antibody GC1008 (... MAH-noh-KLOH-nul AN-tee-BAH-dee ...)

A monoclonal antibody being studied in the treatment of kidney cancer, melanoma, and pulmonary fibrosis. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-TGF-beta monoclonal antibody GC1008 binds to the protein transforming growth factor-beta (TGFß) and may block the growth of cancer cells that make it. Also called GC1008.

antiandrogen (AN-tee-AN-droh-jen)

A drug used to block the production or interfere with the action of male sex hormones.

antiandrogen therapy (AN-tee-AN-droh-jen THAYR-uh-pee)

Treatment with drugs used to block production or interfere with the action of male sex hormones.

antiangiogenesis

Prevention of the growth of new blood vessels.

antiangiogenic

Having to do with reducing the growth of new blood vessels.

antiapoptotic

Something that prevents apoptosis. Apoptosis is a type of cell death in which a series of molecular steps in a cell leads to its death.

antibacterial (AN-tee-bak-TEER-ee-ul)

A substance that kills bacteria or stops them from growing and causing disease.

antibiotic (an-tih-by-AH-tik)

A drug used to treat infections caused by bacteria and other microorganisms.

antibody (AN-tee-BAH-dee)

A type of protein made by plasma cells (a type of white blood cell) in response to an antigen (foreign substance). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Antibodies can work in several ways, depending on the nature of the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen.

antibody therapy (AN-tee-BAH-dee THAYR-uh-pee)

Treatment with an antibody, a substance that can directly kill specific tumor cells or stimulate the immune system to kill tumor cells.

anticachexia (AN-tee-ka-KEK-see-a)

Describes a drug or effect that works against cachexia (loss of body weight and muscle mass).

anticancer antibiotic

A type of anticancer drug that blocks cell growth by interfering with DNA, the genetic material in cells. Also called an antitumor antibiotic or antineoplastic antibiotic.

anticarcinogenic (AN-tee-KAR-sin-o-JEN-ik)

Having to do with preventing or delaying the development of cancer.

anticoagulant

A drug that helps prevent blood clots from forming. Also called a blood thinner.

anticonvulsant (AN-tee-kon-VUL-sant)

A drug or other substance used to prevent or stop seizures or convulsions. Also called an antiepileptic.

antidepressant

A drug used to treat depression.

antidiarrheal (AN-tee-dy-uh-REE-ul)

A substance used to treat diarrhea (frequent and watery bowel movements).

antiemetic (AN-tee-eh-MEH-tik)

A drug that prevents or reduces nausea and vomiting.

antiepileptic (AN-tee-EH-pih-LEP-tik)

A drug or other substance used to prevent or stop seizures or convulsions. Also called an anticonvulsant.

antiestrogen

A substance that blocks the activity of estrogens, the family of hormones that promote the development and maintenance of female sex characteristics.

antifolate

A substance that blocks the activity of folic acid. Antifolates are used to treat cancer. Also called folate antagonist.

antifungal

A drug that treats infections caused by fungi.

antigen

A substance that causes the immune system to make a specific immune response.

antigen-presenting cell

APC. A cell that shows an antigen on its surface to other cells of the immune system. This is an important part of an immune response. Also called APC.

antigen-presenting cell vaccine

A vaccine made of antigens and antigen-presenting cells (APCs). Also called APC vaccine.

antiglobulin test

A laboratory test to identify antibodies that can bind to the surface of red blood cells or platelets and destroy them. This test is used to diagnose certain blood disorders in which patients make antibodies to their own red blood cells or platelets. It is also used to determine blood type. Also called Coomb's test.

antihistamine (AN-tee-HIS-tuh-meen)

A type of drug that blocks the action of histamines, which can cause fever, itching, sneezing, a runny nose, and watery eyes. Antihistamines are used to prevent fevers in patients receiving blood transfusions and to treat allergies, coughs, and colds.

antihormone therapy (AN-tee-HOR-mone THAYR-uh-pee)

Treatment with drugs, surgery, or radiation in order to block the production or action of a hormone. Antihormone therapy may be used in cancer treatment because certain hormones are able to stimulate the growth of some types of tumors.

antimetabolite

A drug that is very similar to natural chemicals in a normal biochemical reaction in cells but different enough to interfere with the normal division and functions of cells.

antimicrobial (AN-tee-my-KROH-bee-ul)

A substance that kills microorganisms such as bacteria or mold, or stops them from growing and causing disease.

antimicrotubule agent

A type of drug that blocks cell growth by stopping mitosis (cell division). Antimicrotubule agents interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer.

antimitotic agent

A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer. Also called mitotic inhibitor.

antineoplastic

A substance that blocks the formation of neoplasms (growths that may become cancerous).

antineoplastic antibiotic

A type of anticancer drug that blocks cell growth by interfering with DNA, the genetic material in cells. Also called an anticancer antibiotic or antitumor antibiotic.

antineoplaston

A substance isolated from normal human blood and urine that is being tested as a type of treatment for some tumors and AIDS.

antioncogene (AN-tee-ON-koh-jeen)

One of a pair of genes (units of heredity passed from parent to offspring) that causes the cell to make a protein that controls cell growth. Cancer may develop when the antioncogene protein does not work because of mutations (changes in the DNA) in the genes. The mutations in the antioncogenes can be inherited or acquired. Also called tumor suppressor gene.

antioxidant (AN-tee-OK-sih-dent)

A substance that protects cells from the damage caused by free radicals (unstable molecules made by the process of oxidation during normal metabolism). Free radicals may play a part in cancer, heart disease, stroke, and other diseases of aging. Antioxidants include beta-carotene, lycopene, vitamins A, C, and E, and other natural and manufactured substances.

antiparasitic

A drug used to treat infections caused by bacteria and parasites. It is also used in the treatment of some cancers.

antiprogestin (AN-tee-proh-JES-tin)

A substance that prevents cells from making or using progesterone (a hormone that plays a role in the menstrual cycle and pregnancy). Antiprogestins may stop some cancer cells from growing and they are being studied in the treatment of breast cancer. An antiprogestin is a type of hormone antagonist.

antiretroviral therapy (AN-tee-REH-troh-VY-rul THAYR-uh-pee)

Treatment with drugs that inhibit the ability of the human immunodeficiency virus (HIV) or other types of retroviruses to multiply in the body.

antisense c-fos

Synthetic genetic material that may slow or stop the growth of cancer cells.

antithymocyte globulin (AN-tee-THIGH-mo-site GLOB-yoo-lin)

A protein used to reduce the risk of or to treat graft-versus-host disease.

antituberculosis (AN-tee-too-ber-kyoo-LOW-sis)

Describes a drug or effect that works against tuberculosis (a contagious bacterial infection that usually affects the lungs).

antitumor (AN-tee-TOO-mer)

Having to do with stopping abnormal cell growth.

antitumor antibiotic

A type of anticancer drug that blocks cell growth by interfering with DNA, the genetic material in cells. Also called an anticancer antibiotic or antineoplastic antibiotic.

antiviral

A drug used to treat infections caused by viruses.

anus (AY-nus)

The opening of the rectum to the outside of the body.

anxiety (ang-ZY-uh-tee)

Feelings of fear, dread, and uneasiness that may occur as a reaction to stress. A person with anxiety may sweat, feel restless and tense, and have a rapid heart beat. Extreme anxiety that happens often over time may be a sign of an anxiety disorder.

anxiolytic

A drug used in the treatment of anxiety and muscle spasms.

aorta (a-OR-tuh)

The largest artery in the body. It carries oxygen-rich blood away from the heart to vessels that reach the rest of the body.

aortocoronary bypass (ay-OR-toh-KOR-uh-NAYR-ee BY-pass)

Surgery in which a healthy blood vessel taken from another part of the body is used to make a new path for blood around a blocked artery leading to the heart. This restores the flow of oxygen and nutrients to the heart. Also called coronary artery bypass and CAB.

AP23573

A drug used to treat soft tissue and bone sarcomas. It is also being studied in the treatment of other solid tumors and hematologic cancer. AP23573 may control the growth of blood vessels to the cancer. It belongs to the family of drugs called rapamycin analogs.

AP5346

A substance being studied in the treatment of head and neck cancer. It may kill cancer cells by carrying an anticancer drug into the tumor. It is a type of platinum compound.

APC

Antigen-presenting cell. A cell that shows an antigen on its surface to other cells of the immune system. This is an important part of an immune response. Also called antigen-presenting cell.

APC vaccine

A vaccine made of antigens and antigen-presenting cells (APCs). Also called antigen-presenting cell vaccine.

APC8015

A vaccine made from immune system cells collected from a patient with prostate cancer. The cells are treated in the laboratory with a growth factor attached to a protein found on prostate cancer cells. APC8015 injected into patients may stimulate T lymphocytes to kill tumor cells that express the prostate protein. Also called Provenge and Sipuleucel-T.

apheresis

A procedure in which blood is collected, part of the blood such as platelets or white blood cells is taken out, and the rest of the blood is returned to the donor. Also called pheresis.

APL

Acute promyelocytic leukemia. An aggressive (fast-growing) type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by an exchange of parts of chromosomes 15 and 17. Also called acute promyelocytic leukemia and promyelocytic leukemia.

aplastic anemia

A condition in which the bone marrow is unable to produce blood cells.

aplidine

A substance that is being studied in the treatment of cancer. It is obtained from a marine organism.

apocrine gland

A type of gland that is found in the skin, breast, eyelid, and ear. Apocrine glands in the breast secrete fat droplets into breast milk and those in the ear help form earwax. Apocrine glands in the skin and eyelid are sweat glands. Most apocrine glands in the skin are in the armpits, the groin, and the area around the nipples of the breast. Apocrine glands in the skin are scent glands, and their secretions usually have an odor. Another type of gland (eccrine gland or simple sweat gland) produces most sweat.

apolizumab

A type of monoclonal antibody that is being studied as a treatment for hematologic (blood) cancers. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.

apoptosis (A-pop-TOH-sis)

A type of cell death in which a series of molecular steps in a cell leads to its death. This is the body’s normal way of getting rid of unneeded or abnormal cells. The process of apoptosis may be blocked in cancer cells. Also called programmed cell death.

appendectomy (A-pen-DEK-toh-mee)

Surgery to remove the appendix (small finger-shaped pouch at the end of the first part of the large intestine).

appendix

A small, fingerlike pouch that sticks out from the cecum (the first part of the large intestine near the end of the small intestine).

appetite (A-peh-tite)

A desire to satisfy a physical or mental need, such as for food, sex, or adventure.

aprepitant (uh-PREH-pih-tunt)

A drug used to prevent and control the nausea and vomiting caused by chemotherapy. It is used together with other anti-vomiting medicines. It belongs to the family of drugs called antiemetic agents. Also called Emend.

aqueous

Having to do with water.

arctigenin

A substance found in certain plants, including burdock. It has shown antiviral and anticancer effects. Arctigenin belongs to a group of substances called lignans.

arctiin

A substance found in certain plants, including burdock. It has shown anticancer effects. Arctiin belongs to a group of substances called lignans.

areola (a-REE-o-la)

The area of dark-colored skin on the breast that surrounds the nipple.

arginine (AR-jih-neen)

One of the twenty common amino acids (building blocks of proteins). Arginine is being studied as a nutritional supplement in the treatment and prevention of cancer and other conditions. Also called L-arginine.

arginine butyrate

A substance that is being studied in the treatment of cancer.

Arixtra (uh-RIKS-truh)

A drug used to prevent blood clots from forming inside blood vessels in the leg. It is being studied in the prevention of blood clots in some cancer patients, including women having surgery for cancer of the reproductive tract. It is a type of anticoagulant. Also called fondaparinux and fondaparinux sodium.

Aromasin (uh-ROH-muh-sin)

A drug used to treat advanced breast cancer and to prevent recurrent breast cancer in postmenopausal women who have already been treated with tamoxifen. It is also being studied in the treatment of other types of cancer. Aromasin causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor. Also called exemestane.

aromatase inhibitor (uh-ROH-muh-tayz in-HIH-bih-ter)

A drug that prevents the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy for postmenopausal women who have hormone-dependent breast cancer.

aromatherapist (uh-ROH-muh-THAYR-uh-pist)

A person who practices a type of complementary medicine called aromatherapy. This therapy uses plant oils that give off strong, pleasant smells to promote relaxation and a sense of well-being. The plant oils are usually inhaled or put on the skin using wet cloths, baths, or massage.

aromatherapy (uh-ROH-muh-THAYR-uh-pee)

A type of complementary and alternative medicine that uses plant oils that give off strong pleasant aromas (smells) to promote relaxation, a sense of well-being, and healing.

aromatherapy infusion (uh-ROH-muh-THAYR-uh-pee in-FYOO-zhun)

The process of heating (without boiling) a mixture of water and an essential oil (scented liquid taken from a plant) to release a pleasant aroma. Aromatherapy infusion may also refer to the process of heating an herb in liquid to release the essential oils. Inhaled oxygen scented by aromatherapy infusion is being studied as a complementary therapy (used in addition to standard treatments) to relieve pain and shorten recovery time in patients undergoing colonoscopy.

aromatherapy massage (uh-ROH-muh THAYR-uh-pee muh-SAZH)

A type of complementary and alternative medicine that uses rubbing and kneading of the skin with plant oils that give off strong, pleasant aromas (smells) to promote relaxation, a sense of well-being, and healing.

aromatic (A-ruh-MA-tik)

Having an odor, which often is pleasant or spicy.

arousal (uh-ROW-zul)

The state of being alert and ready to respond, or waking from sleep.

Arranon (AYR-rah-non)

A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites. Also called nelarabine and 506U78.

arrhenoblastoma (uh-REE-noh-blas-TOH-muh)

A rare type of ovarian tumor in which the tumor cells secrete a male sex hormone. This may cause virilization (the appearance of male physical characteristics in females). Also called androblastoma and Sertoli-Leydig cell tumor of the ovary.

arsenic

A poisonous chemical used to kill weeds and pests. Also used in cancer therapy.

arsenic trioxide (AR-seh-nik try-OK-side)

A drug used to treat acute promyelocytic leukemia (APL) that has not gotten better or that has come back after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Also called Trisenox.

arterial embolization (ar-TEE-ree-al EM-bo-lih-ZAY-shun)

The blocking of an artery by a clot of foreign material. This can be done as treatment to block the flow of blood to a tumor.

arteriogram (ar-TEER-ee-oh-gram)

An x-ray of arteries. The person receives an injection of a dye that outlines the vessels on the x-ray.

arteriography (ar-TEE-ree-AH-gruh-fee)

A procedure to x-ray arteries. The arteries can be seen because of an injection of a dye that outlines the vessels on the x-ray.

artery (AR-tuh-ree)

A blood vessel that carries blood from the heart to tissues and organs in the body.

arthralgia (ar-THRAL-juh)

Joint pain.

arthritis

A disease that causes inflammation and pain in the joints.

artificial pacemaker (AR-tih-FIH-shul PAYS-may-ker)

An electronic device that is implanted in the body to monitor heart rate and rhythm. It gives the heart electrical stimulation when it does not beat normally. It runs on batteries and has long, thin wires that connect it to the heart. Also called pacemaker and cardiac pacemaker.

arzoxifene hydrochloride (ar-ZOX-ih-feen HY-droh-KLOR-ide)

A substance that has been studied in the treatment of breast and endometrial cancers and is now being studied in the treatment of osteoporosis. Arzoxifene hydrochloride binds to estrogen receptors and stops estrogen from getting into breast and uterine cells but increases the amount of estrogen that gets into bone cells. Arzoxifene hydrochloride is made in the laboratory. It is a type of selective estrogen receptor modulator (SERM). Also called LY353381 hydrochloride.

asbestos (as-BES-tus)

A natural material that is made of tiny fibers. Asbestos can cause several serious diseases, including cancer.

ascites (uh-SY-teez)

Abnormal buildup of fluid in the abdomen that may cause swelling. In late-stage cancer, tumor cells may be found in the fluid in the abdomen. Ascites also occurs in patients with liver disease.

ascorbic acid (uh-SKOR-bik A-sid)

A key nutrient that the body needs to fight infection, heal wounds, and keep tissues healthy, including the blood vessels, cartilage, ligaments, tendons, bones, muscle, skin, teeth, and gums. It is an antioxidant that helps prevent tissue damage caused by free radicals. The body does not make or store ascorbic acid, so it must be taken in every day. It is found in many fruits and vegetables, especially green peppers, citrus, strawberries, tomatoes, broccoli, leafy greens, potatoes, and cantaloupe. Also called vitamin C.

asparaginase

An enzyme used in the treatment of cancer. It belongs to the family of drugs called antineoplastics.

aspartate transaminase

An enzyme found in the liver, heart, and other tissues. A high level of aspartate transaminase released into the blood may be a sign of liver or heart damage, cancer, or other diseases. Also called serum glutamic-oxaloacetic transaminase or SGOT.

aspergillosis

An infectious fungal disease that occurs most often in the skin, ears, nasal sinuses, and lungs of people with suppressed immune systems.

Aspergillus (A-sper-JIH-lus)

Fungi commonly found in soil. Certain types of Aspergillus may cause disease, especially in people who have suppressed immune systems.

aspirate (AS-pi-rit)

Fluid withdrawn from a lump (often a cyst) or a nipple.

aspiration (as-per-AY-shun)

Removal of fluid or tissue through a needle. Also, the accidental breathing in of food or fluid into the lungs.

aspirin

A drug that reduces pain, fever, inflammation, and blood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention.

assay (AS-say)

A laboratory test to find and measure the amount of a specific substance.

assessment (uh-SESS-ment)

In healthcare, a process used to learn about a patient’s condition. This may include a complete medical history, medical tests, a physical exam, a test of learning skills, tests to find out if the patient is able to carry out the tasks of daily living, a mental health evaluation, and a review of social support and community resources available to the patient.

assistive device (uh-SISS-tiv…)

A tool that helps a person with a disability to do a certain task. Examples are a cane, wheelchair, scooter, walker, hearing aid, or special bed.

assistive technology (uh-SIS-tiv tek-NAH-loh-jee)

Any device or technology that helps a disabled person. Examples are special grips for holding utensils, computer screen monitors to help a person with low vision read more easily, computers controlled by talking, telephones that make the sound louder, and lifters to help a person rise out of a chair.

asthenia

Weakness; lack of energy and strength.

asthma (AZ-muh)

A chronic disease in which the bronchial airways in the lungs become narrowed and swollen, making it difficult to breathe. Symptoms include wheezing, coughing, tightness in the chest, shortness of breath, and rapid breathing. An attack may be brought on by pet hair, dust, smoke, pollen, mold, exercise, cold air, or stress.

astrocyte (AS-troh-site)

A star-shaped cell that helps nerve cells in the brain and spinal cord work the way they should. An astrocyte is a type of glial cell.

astrocytoma (AS-troh-sy-TOH-muh)

A tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes.

asymmetry

Lack or absence of balanced proportions between parts of a thing.

asymptomatic

Having no signs or symptoms of disease.

AT/RT

An aggressive cancer of the central nervous system, kidney, or liver that occurs in very young children. Also called atypical teratoid/rhabdoid tumor and ATT/RHT.

AT7519M

A substance being studied in the treatment of some types of cancer. AT7519M blocks enzymes needed for cells to divide. It is a type of cyclin-dependent kinase inhibitor. Also called CDK inhibitor AT7519M.

AT9283

A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. AT9283 is a type of serine/threonine protein kinase inhibitor. Also called Aurora kinase inhibitor AT9283.

atamestane

A substance that is being studied in the treatment of cancer. Atamestane blocks the production of the hormone estrogen in the body. It belongs to the family of drugs called antiestrogens.

ataxia

Loss of muscle coordination.

ataxia-telangiectasia

A rare, inherited, progressive, degenerative disease of childhood that causes loss of muscle control, a weakened immune system, and an increased risk of cancer.

ataxic gait (ah-TAK-sik)

Awkward, uncoordinated walking.

atelectasis (at-uh-LEK-tuh-sis)

Failure of the lung to expand (inflate) completely. This may be caused by a blocked airway, a tumor, general anesthesia, pneumonia or other lung infections, lung disease, or long-term bedrest with shallow breathing. Sometimes called a collapsed lung.

athymic nude mouse

A type of laboratory mouse that is hairless, lacks a normal thymus gland, and has a defective immune system because of a genetic mutation. Athymic nude mice are often used in cancer research because they do not reject tumor cells, from mice or other species.

atiprimod (uh-TIH-prih-mod)

A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. Atiprimod may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. Atiprimod is a type of signal transduction inhibitor. Also called azaspirane and SK&F106615.

ATLL

Adult T-cell leukemia/lymphoma. An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma caused by the human T-cell leukemia virus type 1 (HTLV-1). It is marked by bone and skin lesions, high calcium levels, and enlarged lymph nodes, spleen, and liver. Also called adult T-cell leukemia/lymphoma.

ATN-161

A substance being studied in the treatment of some types of cancer. ATN-161 may prevent the spread of tumor cells and the growth of new blood vessels from surrounding tissue to a solid tumor. It is a type of angiogenesis inhibitor.

atorvastatin (uh-TOR-vuh-STA-tin)

A drug used to treat high cholesterol. It is also being studied in the prevention of colon cancer and in the treatment of some types of cancer and other conditions. Atorvastatin is a type of HMG-CoA reductase inhibitor or statin. Also called atorvastatin calcium and Lipitor.

atorvastatin calcium (uh-TOR-vuh-STA-tin KAL-see-um)

A drug used to treat high cholesterol. It is also being studied in the prevention of colon cancer and in the treatment of some types of cancer and other conditions. Atorvastatin calcium is a type of HMG-CoA reductase inhibitor or statin. Also called atorvastatin and Lipitor.

ATP

Adenosine triphosphate. A substance present in all living cells that provides energy for many metabolic processes and is involved in making RNA. ATP made in the laboratory is being studied in patients with advanced solid tumors to see if it can decrease weight loss and improve muscle strength. Also called adenosine triphosphate.

ATRA

All-trans retinoic acid. A form of vitamin A that is made by the body, and can also be made in the laboratory. It is used to treat acute promyelocytic leukemia, usually together with other drugs, and to treat acne. It is being studied in the treatment and prevention of other types of cancer. Also called all-trans retinoic acid, tretinoin, retinoic acid, and vitamin A acid.

atrasentan

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called endothelin-1 protein receptor antagonists.

ATT/RHT

An aggressive cancer of the central nervous system, kidney, or liver that occurs in very young children. Also called atypical teratoid/rhabdoid tumor and AT/RT.

attenuated

Weakened or thinned. Attenuated strains of disease-causing bacteria and viruses are often used as vaccines. The weakened strains are used as vaccines because they stimulate a protective immune response while causing no disease or only mild disease in the person receiving the vaccine.

atypical hyperplasia (AY-TIP-ih-kul HY-per-PLAY-zhuh)

A benign (noncancerous) condition in which cells look abnormal under a microscope and are increased in number.

atypical teratoid/rhabdoid tumor (AY-TIH-pih-kul TER-uh-toyd/RAB-doyd TOO-mer)

An aggressive cancer of the central nervous system, kidney, or liver that occurs in very young children. Also called ATT/RHT and AT/RT.

Augmentin (awg-MEN-tin)

A drug used to treat bacterial infections. Adding the chemical clavulanate potassium to the antibiotic amoxicillin increases the amount of time the antibiotic stays active in the body. Augmentin is a type of combination antibiotic. Also called amoxicillin-clavulanate potassium.

augmerosen (awg-MER-oh-sen)

A substance being studied in the treatment of cancer. It may kill cancer cells by blocking the production of a protein that makes cancer cells live longer and by making them more sensitive to anticancer drugs. It is a type of antisense oligodeoxyribonucleotide. Also called oblimersen, Genasense, and bcl-2 antisense oligodeoxynucleotide G3139.

auricular (aw-RIK-yoo-ler)

Having to do with the ear.

Aurimmune (AW-rih-MYOON)

A substance being studied in the treatment of some types of cancer. Aurimmune is made in the laboratory by binding a cancer-killing protein called tumor necrosis factor (TNF) to the surface of very tiny particles of gold. These TNF-gold particles may kill tumor cells without harming healthy tissue. Also called TNF-bound colloidal gold and colloidal gold-bound tumor necrosis factor.

Aurora kinase inhibitor AT9283 (uh-ROR-uh KY-nayz in-HIH-bih-ter...)

A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. Aurora kinase inhibitor AT9283 is a type of serine/threonine protein kinase inhibitor. Also called AT9283.

autoclave-resistant factor

A substance found in soybeans that may slow down or stop the spread of cancer. This substance does not break down in an autoclave (a device that uses high-pressure steam to kill microorganisms and clean medical equipment).

autoimmune disease (AW-toh-ih-MYOON...)

A condition in which the body recognizes its own tissues as foreign and directs an immune response against them.

autoimmune hemolytic anemia (AW-toh-ih-MYOON hee-moh-LIH-tik uh-NEE-mee-uh)

A condition in which the body’s immune system stops red blood cells from forming or causes them to clump together. Autoimmune hemolytic anemia can occur in patients who have chronic lymphocytic leukemia (CLL). Also called immune complex hemolytic anemia and immunohemolytic anemia.

autologous (aw-TAH-luh-gus)

Taken from an individual's own tissues, cells, or DNA.

autologous bone marrow (aw-TAH-luh-gus bone MAYR-oh)

In transplantation, refers to a person's own bone marrow. Bone marrow is the soft, sponge-like tissue in the center of most large bones that produces white blood cells, red blood cells, and platelets.

autologous bone marrow transplantation (aw-TAH-luh-gus bone MAYR-oh tranz-plan-TAY-shun)

A procedure in which bone marrow is removed from a person, stored, and then given back to the person after intensive treatment.

autologous lymphocyte (aw-TAH-luh-gus LIM-foh-site)

In transplantation, refers to a person’s own white blood cells. Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infections and other diseases.

autologous stem cell transplantation (aw-TAH-luh-gus ... tranz-plan-TAY-shun)

A procedure in which blood-forming stem cells (cells from which all blood cells develop) are removed, stored, and later given back to the same person.

autologous tumor cell (aw-TAH-luh-gus TOO-mer sel)

A cancer cell from an individual's own tumor.

autonomic nervous system (AW-toh-NAH-mik NER-vus SIS-tem)

ANS. The part of the nervous system that controls muscles of internal organs (such as the heart, blood vessels, lungs, stomach, and intestines) and glands (such as salivary glands and sweat glands). One part of the autonomic nervous system helps the body rest, relax, and digest food and another part helps a person fight or take flight in an emergency. Also called involuntary nervous system and ANS.

autophagy (aw-TOF-uh-jee)

A normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Avastin (uh-VAS-tin)

A monoclonal antibody used in the treatment of colorectal cancer that has spread. It is also being studied in the treatment of other types of cancer. Avastin binds to vascular endothelial growth factor (VEGF) and may stop the growth of new blood vessels needed for tumors to grow. It is a type of antiangiogenesis agent. Also called bevacizumab.

Avelox (A-veh-lox)

A drug used to treat bacterial infections. It is a type of fluoroquinolone. Also called moxifloxacin and moxifloxacin hydrochloride.

Avita

A topical preparation of tretinoin that is used to treat acne. Tretinoin is a form of vitamin A.

Avodart

A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor. Also called dutasteride and GG745.

avoidance (uh-VOY-dunts)

The act of staying away from people, places, and thoughts that may cause anxiety, pain, or unpleasant feelings. Some types of cancer-related avoidance include refusing to accept a cancer diagnosis or get treatment, and using alcohol or other drugs to forget about having cancer.

axilla (ak-SIL-a)

The underarm or armpit.

axillary (AK-sih-LAYR-ee)

Pertaining to the armpit area, including the lymph nodes that are located there.

axillary dissection (AK-sih-LAYR-ee dy-SEK-shun)

Surgery to remove lymph nodes found in the armpit region. Also called axillary lymph node dissection.

axillary lymph node (AK-sih-LAYR-ee limf ...)

A lymph node in the armpit region that drains lymph channels from the breast.

axillary lymph node dissection (AK-sih-LAYR-ee limf…dy-SEK-shun)

Surgery to remove lymph nodes found in the armpit region. Also called axillary dissection.

axitinib (AX-ih-TIH-nib)

A substance being studied in the treatment of some types of cancer. Axitinib blocks growth factor receptors and may prevent the growth of new blood vessels needed for tumors to grow. It is a type of tyrosine kinase inhibitor and angiogenesis inhibitor.

azacitidine (ay-zuh-SITE-ih-deen)

A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called antimetabolites. Also called Vidaza and Mylosar.

azaspirane

A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. Azaspirane may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. Azaspirane is a type of signal transduction inhibitor. Also called atiprimod and SK&F106615.

AZD0530

A substance being studied in the treatment of some types of cancer. AZD0530 blocks enzymes needed for cancer growth. It is a type of tyrosine kinase inhibitor.

AZD2171

A substance that is being studied in the treatment of some types of cancer. It belongs to the families of drugs called angiogenesis inhibitors and vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors.

azoxymethane

A substance that is used in cancer research to cause colon tumors in laboratory animals. This is done to test new diets, drugs, and procedures for use in cancer prevention and treatment.

AZQ

Diaziquone. An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system. Also called diaziquone.

AZT

A drug that inhibits the human immunodeficiency virus (HIV) that causes AIDS. Also called zidovudine.

"Let's prevent and against cancer"